Park et al. [23] have reported that 6-Shogalo, an active compound in ginger, alleviates DNCB-induced AD-like skin lesions and scratching behavior by inhibiting immune mediators, including IL-4 and IL-13, via regulation of the ROS/mitogen-activated protein kinase (MAPKs)/Nrf2 signaling pathway. The gene discussed is IL4; the disease is Alzheimer disease.