Although genetic biomarkers, such as KL-6, SP-D, and HLA-DR2 alleles, or antibodies in the serum of patients with RA, such as anti-cyclic citrullinated or anti-citrullinated protein antibodies, were suggested as biomarkers to detect the onset of fibrosis, their detection accuracy is limited [10]. The gene discussed is MUC1; the disease is rheumatoid arthritis.