ADAMTS13 and laryngotracheoesophageal cleft: Furthermore, ADAMTS13:AC levels show better diagnostic performance with higher sensitivity, specificity, and AUC for PVT detection than biomarkers of coagulation activation, anticoagulation, fibrinolysis, endothelial injury, and inflammation [27,28,29], indicating that ADAMTS13:AC levels are most closely associated with PVT development in patients with LC.