Univariate and multivariate analysis demonstrated that ADAMTS-13:AC <18.8% is a significant risk factor for PVT in patients with LC (OR: 1.56; 95% confidence [CI]: 1.10–2.34; p = 0.0052) (OR: 1.67; 95% confidence [CI]: 1.21–3.00; p = 0.002) (Table 2). The gene discussed is ADAMTS13; the disease is laryngotracheoesophageal cleft.