In individuals with a history of low physical activity, exercise for six months produced changes in the DNA methylation of 7663 genes, including some related to obesity, such as the cAMP response element-binding protein 4 (CREB4), elongation of very long-chain fatty acid proteins (ELOV), glucose transporter 4 (GLUT4), and hormone-sensitive lipase (HSL) [23,27]. Here, LIPE is linked to obesity due to melanocortin 4 receptor deficiency.