TFR2 and hemochromatosis type 1: Hemochromatosis is an autosomal-recessive disorder caused by mutations in the genes involved in iron metabolism responsible for the abnormal increase in intestinal iron absorption [31] as a consequence of mutations in several genes, including HFE, transferrin receptor 2 (TFR2), hepcidin, ferroportin (SLC40A1), and hemojuvelin (HFE2) [31,33,34,92,96].