Heterotrimeric G proteins are required for the Kidney Injury Molecule-1 (KIM-1)-mediated clearance of renal tubular epithelial cells in an acute kidney injury (AKI) model [205], as is the junctional adhesion molecule-like protein (JAML), which mediates macrophage polarisation for injury resolution [206]. This evidence concerns the gene HAVCR1 and acute kidney injury.