AIRE and autoimmune polyendocrinopathy: As shown in Table 2A, AIRE promoter gene polymorphisms identified in APS patients were: the -230Y (C/T), the -230T and the -655R (G/A), which also occurred in HD controls (Table 2B); the -261M (C/A), the -380S (C/G), the -191M (C/A), and the -402S (C/G), which were exclusive of four different patients.