KISS1 and precocious puberty: In previous studies, rs7538038 KISS1 was linked with AAM (the G allele was a genetic factor of early AAM) [53], central precocious puberty in girls (allele G was risky for central precocious puberty) [54], BW and endometrial hyperplasia (as part of inter-genic interworkings, [31,40], respectively).