BIN1 and Alzheimer disease: In particular, the association between individual MBI domains and 23 genetic loci known to be linked with AD risk was explored: PICALM, HLA-DRB5, MEF2C, ABCA7, CELF1, CD33, DSG2, CD2AP, CR1, CLU, CASS4, BIN1, FERMT2, SORL1, NME8, INPP5D, EPHA1, MS4A4A, PTK2B, SLC24A4-RIN3, MS4A6A, MS4A4E, and ZCWPW1 [22].