STAT3 and breast cancer: For example, DLX6-AS1 (DLX6 antisense RNA 1) was found to promote distant bone metastasis in breast cancer through the modulation of miR-9-5p and miR-124-3p and the subsequent induction of Wnt/β-catenin signaling [96], HOTAIR has been found to promote lymph node metastasis [83], hsa_circ_102229 has been found to be associated with lung metastasis [62], and circKIF4a has been shown to promote brain metastasis through STAT3 signaling [56].