Since Ca2+ handling by the sarcoplasmic reticulum was enhanced, unlike the myofibrillar Ca2+-stimulated ATPase activity at early and moderate stages of heart failure due to myocardial infarction, it appears that the hypertrophied right ventricle may serve as a compensatory mechanism to support the function of the left ventricle at early and moderate stages of heart failure. Here, DNAH8 is linked to heart failure.