Numerous pathological conditions such as hypertension, diabetes, obesity, aging, atherosclerosis, myocardial infarction, valvular heart disease and different types of cardiomyopathies are known to cause cardiac hypertrophy and heart failure upon increasing ventricular tension as a consequence of increased pre-load or after-load, as well as elevated levels of several vasoactive hormones, including catecholamines and angiotensin II [1,2,3,4,5,6]. The gene discussed is AGT; the disease is heart failure.