Mostafavi-Pour et al., 2017, investigated the role of Vit C and quercetin (Q) in the induction of NRF2-mediated OS in cancer cells, examining the antiproliferative effects of Vit C and Q. The results showed a significant decrease in NRF2 mRNA expression and protein levels after treatment of breast cancer cells with Vit C and Q: the nuclear/cytosolic NRF2 ratio was reduced 1.7-fold in MDA-MB 231 cells, 2-fold in MDA-MB 468 cells, 1.4-fold in MCF-7 cells, and 1.2-fold in A549 cells. The gene discussed is NFE2L2; the disease is cancer.