In summary, the phagocytosis of neutrophils during pneumococcal infection occurs through a dectin-2-CARD9-dependent mechanism, but responses such as neutrophil recruitment and macrophage production of TNF-α, CXCL1, and CXCL2 are mediated by the signaling pathways of other CLRs, not dectin-2. This evidence concerns the gene CLEC6A and pneumococcal infection.