Therefore, keeping in mind that in AD patients brain tissue displays increased GADD45A protein levels in the hippocampus and occipital lobe and that GADD45A has a crucial function in the response to DNA strand breakage induced by Aβ in neurons [18], our study provides robust evidence that GADD45A will become a promising new target to be considered for neurodegenerative diseases, as well as new therapies for AD. Here, GADD45A is linked to Alzheimer disease.