METTL3 and cancer: After irradiation, the METTL3 and M6A modification in GSC increase, causing Human antigen R (HuR), an essential regulator of RNA metabolism, to bind more effectively to M6A -modified RNA, leading to an enhanced stability of Sex-determining region Y-box2 (SOX2), an important transcriptional regulator in pluripotent stem cells including cancer stem cells.