The above figure shows that statistically significant changes are observed between the control group (CTR) and grades G2–G4 for VEGF-A, between CTR and grade G4, and between grade G4 and grades G1 and G2 for VEGF-R2, and between CTR and all grades of glioma, and between G2 and G4 for FGF-2. The gene discussed is VEGFA; the disease is glioma.