hCSF1-5XFAD (shortened to 5XFAD from now on) mice overexpress co-integrated APP and PSEN1 transgenes containing five familial AD mutations (the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1) and recapitulate aspects of human AD, including age-dependent cognitive deficits, amyloid accumulation and neuroinflammation [25]. This evidence concerns the gene PSEN1 and age.