In another study, the combination of PU-H71 with DHEA, a glucose-6-phosphate dehydrogenase (G6PD) inhibitor, demonstrated a synergistic anti-tumor effect on TNBC cells by suppressing Nrf2, a key transcription factor regulating antioxidants and metabolic enzymes and leading to apoptosis, suggesting that G6PD inhibitors could be valuable additions to combination therapies targeting cellular oxidative balance [41]. Here, G6PD is linked to neoplasm.