Interestingly, there is evidence of peripheral resistance to FGF23 in ADPKD patients, likely due to the disease and its klotho deficiency, considering that the tubular maximum phosphorus reabsorption per glomerular filtration rate surpasses the anticipated levels based on FGF23 exposure [127,131,132,133,134]. The gene discussed is FGF23; the disease is autosomal dominant polycystic kidney disease.