According to these studies, miR-124-3p inhibits Lamin A/C, which increases VSMC death under cyclic strain [48]; miR-421 modifies the renin–angiotensin system and ACE2 protein levels, potentially influencing both apoptosis and hypertension [57]; moreover, increased miR-21 expression may prevent stretch-induced apoptosis in HASMCs [58]. This evidence concerns the gene REN and hypertensive disorder.