Although murine adipocyte cell lines express MC2R, and ACTH can regulate adipocyte function [33], human mature adipocytes only express low levels of MC2R, and ACTH does not regulate lipolysis in mature human adipose tissue [55], supporting our findings that inflammatory cells and adrenocortical hormones play a role in myelolipoma formation in CAH. Here, POMC is linked to adrenal gland myelolipoma.