We show in vitro that adrenocortical cells exposed to the hormonal milieu typical of an untreated CAH patient display an increase in PRKCH, PGM2L1, LYPD6, NDRG4, and ADAMTS14, factors involved in tumorigenesis, cell cycle progression, and regulation. This evidence concerns the gene PGM2L1 and congenital adrenal hyperplasia.