During tumor progression, POSTN has been reported to play a critical role in the formation and remodeling of cancer tissue microenvironments via CAFs and accelerates cell adhesion, survival, invasion, angiogenesis, metastasis, and epithelial–mesenchymal transition (EMT) through interactions with tumor cell–surface receptor integrins such as αvβ3, αvβ5, and α6β4 to modulate intracellular signaling [19,21,25]. The gene discussed is POSTN; the disease is cancer.