LAMB3 and cancer: The proposed mechanism related to LAMB3 involved in cancer cell migration and invasion is that laminin-332 overexpression in cancer cells can be switched from an anchorage protein to a free soluble protein favoring migration and invasion of cancer; laminin β3 chain and collagen VII interaction promotes carcinogenesis via activation of PI3K signaling pathway, which results in inhibition of apoptosis and increased tumor invasion.