For instance, the assembly process for a signaling-competent complex between KRAS and RAF dimers may be affected by the relative stoichiometry between KRAS, other RAS family proteins, RAFs, other downstream effectors, and upstream regulators (i.e., GEFs and GAPs) as well as by their expression levels that vary in many types and stages of normal or RAS-driven cancer cells [58,59,60,61]. Here, KRAS is linked to cancer.