Similarly, a prospective study in patients with primary brain tumors showed that although the concentration of EVs in those who developed PE was similar to those who did not, the pro-coagulant annexin V+ and annexin V+/CD142+ EVs were significantly higher in patients with PE than in those without PE [119], suggesting that not only the quantity but also the quality of EVs could be used for their predictive value (Figure 2). This evidence concerns the gene ANXA5 and brain neoplasm.