Higher levels of TF-expressing circulating EVs have been described, not only in patients with DVT [116] but also in individuals with a pure predisposition to VTE, such as those with factor V Leiden [117] or carriers of prothrombin gene mutations, in whom EVs may play a role in the development of VTE by increasing thrombin generation [118]. The gene discussed is TF; the disease is deep vein thrombosis.