AKT1 and Alzheimer disease: From the heatmap in Figure 6, it can generally be seen that in both AD and non-AD subjects, there was an upregulation of almost all the genes involved in the inflammatory process, especially after 48 h of treatment, except for P38 and Akt, where it appears that treatments resulted in negligible effects on P38 transcriptional levels while Akt was downregulated.