MAPT and Alzheimer disease: Meanwhile, at 48 h of incubation, the same morphology appeared for the co-cultures treated with the CSF of patients of groups Aβ-Tau, non-AD, and Control in the co-cultures, while the neural network of the co-cultures treated with the CSF of patients of group Aβ+Tau had missing, substantially and completely, neurofilaments and spheroid, and many cells were in suspension.