VDR and melanoma: Although the CPL304110 did not influence the mRNA level for VDR in A375 melanoma cells (Figure 5A), it showed a decrease after simultaneous treatment with CPL304110 and 1,25(OH)2D3 (p < 0.01 vs. control and p < 0.05 vs. treatment with 304–110 alone, Figure 5A).