KIT and melanoma: Recently we also showed that 1,25(OH)2D3 and other vitamin D derivatives significantly augment the efficacy of cediranib, an oral tyrosine kinase inhibitor of VEGFR1-3, PDGFR, and c-KIT, against A375 and SK-MEL-28 melanoma cell lines, out of four human cell lines that were tested, as well as against patient-derived melanoma cells [21,22].