Most importantly, we noticed an increase in the mRNA level for FGFR2 in RPMI7951 melanoma cells treated with each of our tested FGFR inhibitors and 1,25(OH)2D3 (Figure 6F, p < 0.05 for both) or with 1,25(OH)2D3 alone (Figure 6F, p < 0.05), but not for monotreatment with CPL304110 nor AZD4547. The gene discussed is FGFR2; the disease is melanoma.