In the case of LGMD2I, two studies have shown improvement in the respiratory function of FKRP-mutant mice (FKRPP448L), one in response to ribitol treatment [16] and the other to a combination of tamoxifen and raloxifene [17]. The gene discussed is FKRP; the disease is autosomal recessive limb-girdle muscular dystrophy type 2I.