Examples include the breast cancer gene 1 (BRCA1) in ovarian and breast cancer, the Von Hippel–Lindau tumor suppressor (VHL) in clear renal cell carcinoma and the O-6-methylguanine-DNA methyltransferase (MGMT) repair gene in glioblastoma (GB) [17]. The gene discussed is MGMT; the disease is clear cell renal carcinoma.