Davis et al. showed that if podocytes are treated with nucleosome-associated dsDNA fragments, a common marker found in the blood of Lupus patients, IFNγ-inducible protein 16 (IFI16) triggers the expression of both IFNβ and APOL1 and the activation of the cGAS/STING pathway [43]. Here, CGAS is linked to systemic lupus erythematosus.