In the meantime, necrosis represents an acute and severe reply to endotoxin action in gut cells when the innate and adaptive functional immune system reacts to pro-inflammatory Th1 and Th2 cytokines releasing, offering protection against PAMPs/DAMPs by monocytes and T lymphocytes activation, being observed in duodenal tissue samples with acute inflammation recovered from patients with hepatic cirrhosis and steatosis, compared with controls, using Annexin V-FITC/PI dual stain (Figure 10G,I). This evidence concerns the gene ANXA5 and Cirrhosis.