Moreover, in murine xenograft GB, miR-7 was capable of inhibiting tumor angiogenesis and growth by directly targeting the O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) gene [32], and these same phenotypes were achieved when miR-7 targeted Raf-1 proto-oncogene (RAF1) in GB cell lines [45]. This evidence concerns the gene OGT and neoplasm.