Infection with WSN viruses significantly increased the expression of proteins associated with CD54/ICAM-1, IGFBP-2, IGFBP-5, IGFBP-6, CHI3L1, MPO, OPN, cystatin C, and LDL R. The proteins CD54/ICAM-1, IGFBP-5, and MPO were not detected and proteins IGFBP-6, CHI3L1, OPN, CD105/Endoglin, and LDL R were significantly decreased in the brains infected with NS80 and NS80ad viruses. The gene discussed is SPP1; the disease is infection.