Targeted to GBM (which overexpress the ephrin type-A receptor 3 (EphA3)) by an anti-EphA3 antibody, GBM cells and a subcutaneous GBM mice model treated with these ~46 nm GNPs were irradiated with an NIR laser and studied for their apoptosis induction, resistance mechanism, and antiglioma effects. This evidence concerns the gene EPHA3 and glioblastoma.