At the gene level, there are 18 genes showing more than five hotspots across all cancer types (in order, TP53, PIK3CA, PTEN, APC, KRAS, CTNNB1, FBXW7, CDKN2A, ARID1A, PIK3R1, NFE2L2, EGFR, NRAS, BRAF, HRAS, VHL, IDH1, ERBB2). The gene discussed is BRAF; the disease is cancer.