Additionally, dysregulation in the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway further accentuates the demand for glutamine, driving an accelerated flux through the tricarboxylic acid (TCA) cycle to fuel the biosynthetic requirements of rapidly proliferating cancer cells [31]. The gene discussed is MTOR; the disease is cancer.