In these clinical studies, CB-839 has been administered with nivolumab as a treatment for melanoma, renal cell carcinoma (RCC), and non-small cell lung cancer (NSCLC); everolimus for RCC; palbociclib for KRAS-derived PDAC, NSCLC and CRC; and cabozantinib for advanced RCC. The gene discussed is KRAS; the disease is renal cell carcinoma.