Our findings revealed elevated levels of Notch1, CD133, and Nestin expression in glioblastomas from the GFAP-Cre; KrasG12D; APCL/+; p53L/L mice when compared to brain sections from the GFAP-Cre;KrasG12D;p53L/L group. This evidence concerns the gene PROM1 and glioblastoma.