Hematoxylin and eosin (H&E) staining highlights key aspects of human glioma, such as hemorrhage, increased cellularity, nuclear vascular proliferation, and necrosis in the brain tumor tissues of GFAP-Cre; KrasG12D; APCL/+; p53L/L mice (Figure 2Bi–Biii). Here, APC2 is linked to central nervous system cancer.