Moreover, analysis of publicly available Gene Expression Omnibus data (GSE39582) revealed that Sox2 expression is higher in CRC tissues than in normal colon tissues, whereas ACSS2 expression is higher in normal colon tissues than in CRC tissues (Supplementary Figure S4B), suggesting an inverse relationship between Sox2 expression and ACSS2 expression. The gene discussed is SOX2; the disease is colorectal carcinoma.