However, the role of dysregulation of miR-448 expression in the pathogenesis of pancreatic cancer (reduced expression of miR-448 inhibits apoptosis and stimulates the proliferation of cancer cells by stimulating Rab2B) and colon cancer (reduced expression of miR-448 increases the expression of IDO1 protein and thus stimulates apoptosis of CD8+ lymphocytes, intensifying cancer progression) or Hodgkin’s lymphoma (overexpression of miR-448 increases the level of DCLK1 protein and thus increases the proliferation and invasion of cancer cells) [31,32]. The gene discussed is CD8A; the disease is familial pancreatic carcinoma.