Amplification of cyclin D1 and mutation in CDK4/6 and other CDKs are associated with resistance to BRAF inhibitors [100], and inclusion of CDK inhibitors, including CDK12 [101], which is activated via the RAS/MAPK pathway, with anti-BRAF therapy is being investigated for overcoming resistance to targeted therapy in multiple types of cancer with BRAFV600E mutations. This evidence concerns the gene BRAF and cancer.