A recent study using ctDNA detected the hypermethylation of zinc finger and SCAN domain containing 12 (ZSCAN12) and/or oxytocin (OXT) in 9/11 and 5/20 women with advanced and non-advanced endometrial cancer, respectively, giving a sensitivity of 98%, specificity of 97% and an area under the curve (AUC) of 0.99 [52]. The gene discussed is ZSCAN12; the disease is endometrial cancer.