PRKCA and cancer: There are several isoforms of PKC, and the phospho-specific antibody used in our study is only able to detect PKCα and PKCb, both of which are regulated by diacylglyercol produced by phospholipase C. Activation of PKCα and PKCα isoenzymes have often been linked to more malignant phenotypes, while PKCδ is thought to mediate anti-cancer effects such as apoptosis [28].