Specifically, macrophage subpopulations were found to comprise a greater proportion of total immune cell infiltrates in PNF from 7-month-old Dhh-Cre;Nf1flox/flox mice relative to both age-matched WT littermates and 2-month-old Dhh-Cre;Nf1flox/flox pre-tumor controls. Here, DHH is linked to neoplasm.