Likewise, the persistence of EBV in BL (versus non-EBV associated BL) further shows methylation marks on RUNX1 and lysine (K)-specific demethylase 2B (KDM2B), which, although having opposing roles in tumor progression, are significantly methylated in EBV-associated BL when compared to non-EBV-associated BL [174]. The gene discussed is RUNX1; the disease is Burkitt lymphoma.