In drug-resistant breast cancer cells, the activation of the extrinsic pathway by caspase-8 via DR4/5 and Fas was inhibited and the activation of the intrinsic pathway by Bax, Cyt c release, and the caspase cascade was induced, suggesting that resistance to apoptotic signaling pathways is regulated independently [124]. This evidence concerns the gene TNFRSF10A and breast carcinoma.