Nevertheless, ICD improves the low immunogenicity of tumor cells in the tumor microenvironment, and the release of large amounts of DAMPs such as CRT, ATP, and HMGB1 during ICD induction activates the ICD signaling pathway, in turn promoting DC maturation and activating cytotoxic T lymphocytes (CTLs); thus, antitumor effects are enhanced. The gene discussed is HMGB1; the disease is neoplasm.