Docetaxel treatment increases AP-1 binding activity and induces Gadd153 expression, leading to apoptotic cell death in gastric cancer cells [118], and the induction of Gadd153 expression sensitizes calls to anticancer agents such as VP-16 and cisplatin, leading to apoptosis via the coactivation of Bax and JNK and the downregulation of Bcl-2 [119]. The gene discussed is JUN; the disease is gastric cancer.