CYBB and neoplasm: Then, through activation of the NADPH oxidase 2 (NOX2) complex, there is an increase in the concentration of ROS and lysosomal pH from 5.0 to 8.5, lipid peroxidation, and a membrane-damaging chain reaction, which promotes the leakage of antigens from endosomes and the formation of peptide complexes of tumor antigens and MHC class I [41,42,43,44].