Inhibition of WEE1 using AZD1775 also leads to the activation of type I and II interferon pathways, as well as the infiltration of several immune cell populations, including CD3+ and CD8+ CTLs (cytotoxic T lymphocytes), CD44+ effector/memory T cells, and M1-phenotype macrophages (pro-inflammatory or anti-tumor) in the TME of SCLC. Here, WEE1 is linked to small cell lung carcinoma.