Whilst many studies have demonstrated the inhibitory effect of melatonin on Snail, its influence on other EMT-related transcription factors such as ZEB1 and ZEB2 has also been observed in cancer stem cells obtained from SKOV3 ovarian cells, which are known to show higher expression levels of EMT-related genes, such as ZEB1, ZEB2, Snail and vimentin, compared to parental SKOV3 cells. This evidence concerns the gene VIM and cancer.