SDHB and gastrointestinal stromal tumor: Similarly, INT2GRATE|HPPGL analysis of cases with SDHB variants (n = 15) were negative for personal (except for one) and family history of PGL/PCC ± associated GIST; somatic inactivating alterations in SDHB (except for one); multiple, multifocal, or extra-adrenal tumors; and PGL/PCC metastasis (Table 6).