THs with GTF2I mutations (type A and AB thymomas) were enriched for genes related to human embryonic stem cell pluripotency and Wnt/β-catenin signaling [82], lymphocyte-rich type B1 and B2 thymomas were enriched for genes related to T-cell receptor signaling, CTLA4 signaling, and ICOS/ICOSL signaling, whereas type B3 thymomas overexpressed genes related to G protein-coupled receptor signaling, Toll-like receptor signaling regulation of epithelial–mesenchymal transition (EMT) as well as NF-κB, EGF, FAK, and telomerase signaling. This evidence concerns the gene ICOS and thymoma.